Date of Award

Summer 7-30-2017

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Issifu I. Harruna, Ph.D.

Second Advisor

Ishrat M. Khan, Ph.D.

Third Advisor

James Reed, Ph.D.

Abstract

One of the most significant classes of industrial chemicals is benzalkonium salts. Benzalkonium salts have application in large number of commercial products. Benzalkonium salts enhance cationic surface activity and this particular property results in the salts being useful biocides, detergents, and disinfectants. Their antimicrobial activities depend on the structure of the side alkyl chain. For instance, long alkyl chains of C12 were most effective against fungi, yeast, and ophthalmic solution, C14 were effective against gram-positive bacteria, and C16 were effective against gram-negative bacteria. To add them to the databank of structure activity relationships (SAR) of benzalkonium salts, need for new compounds to kill (bactericide) or inhibit growth (bacteriostatic) of bacteria and other microorganisms. In this study, quaternary salts of benzalkonium compounds were synthesized with an alkyl chain length of C9. The salts were characterized using 1H NMR, 13C NMR, mass spectrometry, and Fourier transform infrared spectroscopy (FTIR).

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