Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome

Seffens, William, Morehouse School of Medicine
Abebe, Fisseha, Clark Atlanta University
Evans, Chad, Morehouse School of Medicine
Wang, Xiao-Qian, Clark Atlanta University

2016-06-08

2010-2019

RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.

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articles

International Journal of Molecular Sciences 17, no. 6 (2016): 1-11.

Clark Atlanta University

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926364/pdf/ijms-17-00830.pdf

10.3390/ijms17060830

http://hdl.handle.net/20.500.12322/cau.ir:2016_seffens_william

http://rightsstatements.org/vocab/InC/1.0/