Document Type

Article

Publication Date

6-8-2016

Department

Department of Physics, Department of Mathematics

Abstract

RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.

Comments

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926364/pdf/ijms-17-00830.pdf

DOI

10.3390/ijms17060830

Source

International Journal of Molecular Sciences 17, no. 6 (2016): 1-11.

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