Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome
Seffens, William, Morehouse School of Medicine Abebe, Fisseha, Clark Atlanta University Evans, Chad, Morehouse School of Medicine Wang, Xiao-Qian, Clark Atlanta University
2016-06-08
2010-2019
RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.
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International Journal of Molecular Sciences 17, no. 6 (2016): 1-11.
Clark Atlanta University
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926364/pdf/ijms-17-00830.pdf
10.3390/ijms17060830
http://hdl.handle.net/20.500.12322/cau.ir:2016_seffens_william
http://rightsstatements.org/vocab/InC/1.0/