Document Type

Article

Publication Date

3-8-2014

Department

Center for Cancer Research and Therapeutic Development, Department of Biological Sciences

Abstract

Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast. These environmental carcinogens elicit their effects through interacting with the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Naturally occurring compounds found in fruits and vegetables shown to have anti-carcinogenic effects also interact with the AhR. This review explores dietary and environmental exposure to chemical carcinogens and beneficial natural compounds whose effects are elicited by the AhR.

DOI

10.4172/2167-0501.1000131

Source

Biochemistry & Pharmacology: Open Access

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