A novel and efficient synthesis of imidazo[1,5-a]pyradines, 2007
Mason, Richard J., Jr.
2000-2009
A one-pot and straightforward synthesis, which results in the formation of imidazo[1,5-a]pyridines, has been intensely investigated. This methodology has been applied to 2,2'-pyridil, ?- pyridoin and 2-benzoylpyridne ketone systems respectively. Treatment of 2,2'-pyridiI, ? -pyridoin or 2-benzoylpyridine with aromatic aldehydes, and ammonium acetate in the presence of hot acetic acid has been shown to give 1-(2-Pyridoyl)-3-phenylimidazolesand 1,3-di-phenylimidazo[1,5-a]pyridines in good to excellent yields. These reactions were carried out without the use of metal catalysts, which is a commonly used methodology for imidazo[1,5-a]pyridine synthesis. A new and efficient synthesis of 1,3-diaryl-[1,5-a]imidazopyridines has also been developed based on the reaction of 2-benzoylpyiridne with aldehydes in the presence of ammonium acetate and hot acetic acid Aldehydes applicable to this reaction include aryl aldehydes, heteroaromatic aldehydes, salicylaldehydes.
text
application/pdf
2007-05-01
dissertation
Doctor of Philosophy (PhD)
Clark Atlanta University
Chemistry
Bu, Xiu (James)
Georgia--Atlanta
http://hdl.handle.net/20.500.12322/cau.td:2007_mason_richard_j