Interest in enrolling minority participants into clinical and behavioral studies has grown due, in part, to the National Institutes of Health requirement that minorities and women be considered for all studies sponsored by NI H. Although the number of minorities and women in clinical trials has increased in recent years, many researchers report challenges to enrolling them in behavioral research studies. The purpose of this article is to describe the P.A.T.I.E.N.C.E. model, a recruitment approach for improving African-American participation in research. The P.A.T.l.E.N.C.E. model is a multifaceted approach to recruitment and derives its name from the acronyms of its components: Passive recruitment, Active recruitment, Training of research staff, Involving the community, Education of research participants, Nurturing participants, Commitment of staff, and Evaluation of the recruitment procedures.