This paper investigated African American college students’ responses to a set of interview questions selected from a larger survey instrument in an exploratory study of basic attitudes about HIV/AIDS. Forty-two participants responded to an interview schedule in an investigation of student attitudinal domains regarding the HIV/AIDS epidemic. Results show that while most students’ attitudes were consistent with expectations, a number of students expressed attitudes that are counterproductive in the fight against HIV/AIDS. Given the epidemic within the African American community, such findings appear ominous and implore strategies, in particular, from the institution whose primary function is the education of its populace. Unless aggressive steps are taken to address the problem across college and university campuses, there can be no lessening of the epidemic’s impact within this community, and thereby no positive impact toward the goal of U.S. lowered rates consistent with recent global trends.