Date of Award

5-1-1989

Degree Type

Thesis

University or Center

Atlanta University (AU)

Degree Name

M.S.

Department

Chemistry

First Advisor

Professor Julian M. Menter

Abstract

The melanocytotoxic phenol, p-hydroxyanisole (monomethylether of hydroquinone, MMEH) is a substrate for mushroom tyrosinase. Kinetic and oxygen electrode studies have been performed compari ng the total (anaerobi c and aerobi c) reaction in the formation of the 1, 2-qui none in the presence and absence of synthetic (Sigma) and "biological" (Sepia) melanin samples. These results show evidence of melanin actively transferring electrons to tyrosi nase; thereby acting as a DOPA-l ike cofactor. These results also reveal major differences in the chemical properties of synthetic and biologically extracted melanin in an in vitro system, thus raising important questions about conclusions that are extended to biological systems, using synthetic melanin.

Included in

Chemistry Commons

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