Date of Award

5-1-1984

Degree Type

Dissertation

University or Center

Atlanta University (AU)

Degree Name

Ph.D.

Department

Biology

First Advisor

Dr. Roy Hunter, Jr.

Abstract

A histochemical and ultrastructural study of the liver of normal and Dispersion yellow 3 (Dy3) treated tadpoles was conducted. The study reveal ed that Dy3 caused marked progress i ve increases in aci dphosphatase and beta-glucuronidase activity. Progressive decrease in alkaline-phosphatase activity was noted following exposure to Dy3.

Exposure to Dy3 resulted in edema and impeded swimming movement in tadpoles examined macroscopically. Microscopic observation revealed damage to blood vessels and bile canaliculi in early stages. Prolonged exposure resulted in progressive disruption of connective tissue and cytoplasm, followed by destruction of the mitochondria, endoplasmic reticulum and nuclei of hepatic cells.

Included in

Biology Commons

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