Date of Award
University or Center
Atlanta University (AU)
Dr. James H. Penn
The purpose of this study was to analyze the effects of the drug, flurazepam dihydrocloride on the growth and motility of Tetrahymena pyriformis maintained under axenic conditions.
Growth cultures containing the drug and the organisms were cultivated at 26°C for five days, with optical readings taken at 24-hr intervals. These readings were determined by turbidity using a Spectronic 20. The organisms were examined by Scanning Electron Microscopy to determine sites of drug activity on the organisms. Results revealed that flurazepam dihydrocloride caused the inhibition of growth and motility of l· pyriformis. Scanning Electron Microscope studies revealed that the primary sites of activity of T. pyriformis are upon (1) the cilia, preventing motility making the organism unable to reach its food, (2) the buccal cavity, hendering the oral apparatus that also has cilia, and (3) the pellicle, comprising the outer membrane of the organism, which is destroyed
Stovall, Sonja R., "The effects of flurazepam dihydrochloride on the growth and motility of Tetrahymena pyriformis as seen by the scanning electron microscope" (1985). ETD Collection for AUC Robert W. Woodruff Library. 1979.