Characterization of Pyrazinamide mono-resistant strains of Mycobacterium Tuberculosis complex isolates submitted to centers for disease control from United States public health laboratories for drug susceptibility testing, 2011

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Title: Characterization of Pyrazinamide mono-resistant strains of Mycobacterium Tuberculosis complex isolates submitted to centers for disease control from United States public health laboratories for drug susceptibility testing, 2011
Author: Franklin, Jameelah Atiya
Decade: 2010-2019
Abstract: Pyrazinamide (PZA) is an important first line drug for the treatment of tuberculosis. While isolates of Mycobacterium bovis are intrinsically resistant to PZA and susceptible to all other anti-tuberculosis drugs, Mycobacterium tuberculosis isolates resistant to PZA are usually resistant to other first line anti-tuberculosis drugs as well. However, rare strains of M tuberculosis resistant only to PZA have been described in a previous study. Recently, methodological problems with PZA testing have been described previously, and Centers for Disease Control and Prevention (CDC) has recognized an increase in submission of PZA mono-resistant M. tuberculosis isolates from US public health labs.
Document Type: text
Format: application/pdf
Date of Award: 2011-05-01
Degree Type: thesis
Degree Name: Master of Science (MS)
Granting Institution: Clark Atlanta University
Department: School of Arts and Sciences, Biology
Advisor: Logan, David A.
Campbell, Marjorie G.S.
Metchock, Beverly
Institution: Clark Atlanta University
Geographic Location: Georgia--Atlanta
Handle: http://hdl.handle.net/20.500.12322/cau.td:2011_franklin_jameelah_a