Date of Award

5-1-2011

Degree Type

Thesis

University or Center

Clark Atlanta University(CAU)

School

School of Arts and Sciences

Degree Name

M.S.

Department

Biology

First Advisor

Dr. David A. Logan

Second Advisor

Dr. Marjorie G.S. Campbell

Third Advisor

Dr. Beverly Metchock

Abstract

Pyrazinamide (PZA) is an important first line drug for the treatment of tuberculosis. While isolates of Mycobacterium bovis are intrinsically resistant to PZA and susceptible to all other anti-tuberculosis drugs, Mycobacterium tuberculosis isolates resistant to PZA are usually resistant to other first line anti-tuberculosis drugs as well. However, rare strains of M tuberculosis resistant only to PZA have been described in a previous study. Recently, methodological problems with PZA testing have been described previously, and Centers for Disease Control and Prevention (CDC) has recognized an increase in submission of PZA mono-resistant M. tuberculosis isolates from US public health labs.

Included in

Biology Commons

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