Date of Award
5-1-2011
Degree Type
Thesis
University or Center
Clark Atlanta University(CAU)
School
School of Arts and Sciences
Degree Name
M.S.
Department
Biology
First Advisor
Dr. David A. Logan
Second Advisor
Dr. Marjorie G.S. Campbell
Third Advisor
Dr. Beverly Metchock
Abstract
Pyrazinamide (PZA) is an important first line drug for the treatment of tuberculosis. While isolates of Mycobacterium bovis are intrinsically resistant to PZA and susceptible to all other anti-tuberculosis drugs, Mycobacterium tuberculosis isolates resistant to PZA are usually resistant to other first line anti-tuberculosis drugs as well. However, rare strains of M tuberculosis resistant only to PZA have been described in a previous study. Recently, methodological problems with PZA testing have been described previously, and Centers for Disease Control and Prevention (CDC) has recognized an increase in submission of PZA mono-resistant M. tuberculosis isolates from US public health labs.
Recommended Citation
Franklin, Jameelah Atiya, "Characterization of pyrazinamide mono-resistant strains of Mycobacterium tuberculosis complex isolates submitted to centers for disease control from United States public health laboratories for drug susceptibility testing" (2011). ETD Collection for Robert W. Woodruff Library, Atlanta University Center. Paper 198.
http://digitalcommons.auctr.edu/dissertations/198