Date of Award
University or Center
Clark Atlanta University(CAU)
Dr. Shafiq Khan
Transforming growth factor-beta (TGF-β) has a variety of roles including cell growth inhibition, stimulation of proliferation, differentiation, apoptosis and extracellular matrix (ECM) formation. TGF-β inhibits growth of the epithelial cells in the prostate gland. The ability of TGF-β to inhibit cell growth enables it to act as a potent tumor suppressor. Here, we show that TGF-β has different effects on proliferation in DU145 (TGF-β- responsive) and PC3M (TGF-β - resistant) prostate cancer cell lines. RT-PCR analysis and Real-time PCR data have determined the varying levels of AP-1 family members in both cell lines. In PC3M and DU145 cells, we have shown that TGF-p exerts opposite effects on JunD, cFos and Fra2 expression, suggesting that AP-1 family members may be involved in the differential effects of TGF-β in these cell lines. The present observation confirms an intact inhibitory role of TGF-β on proliferation in DU145 cells, and shows a non-inhibitory function in PC3M cell growth. In PC3M cells TGF-β may exert effects leading to the metastatic nature of this cell line.
Russell, Daree E., "The role of AP-1 proteins in the transforming growth factor-beta signaling pathway in prostate cancer" (2005). ETD Collection for AUC Robert W. Woodruff Library. 2178.