Date of Award
University or Center
Clark Atlanta University(CAU)
Ishrat M. Khan, Ph.D
β-sitosterol/polyethylene glycol complexes were prepared by solution blending in 1,2-dichloroethane. 1,2-Dichloroethane is a good solvent for the two components. The complexes were studied by Nuclear Magnetic Resonance (NMR) spectroscopy and Differential Scanning Calorimetry (DSC). These complexes have the possibility of reducing the swelling of benign prostatic hyperplasia and diminishing inflammation. β-sitosterol is hydrophobic and thus it is difficult to deliver the sterol into aqueous systems. Aqueous system delivery is required for effective blood circulation. Polyethylene glycol was used because of its amphiphilic properties. Proton NMR (1HNMR) of the complexes shows that the methylene (CH2) protons of the PEG are slightly shifted because of its non-covalent interaction with β-sitosterol. The complex formation was supported by 2-D NMR (NOESY) spectroscopy. NOESY spectra show cross peaks, indicating interaction between the two components. DSC of the complexes show thermal characteristics that are different from the individual components. In particular, the PEG in the complexes shows a lower melting point and decreased crystallinity compared to the pure PEG. The melting point is lowered from 62 °C to 55 °C for the PEG 35,000/β-sitosterol (10%) complex. The NMR and DSC studies suggest the formation of a relatively stableβ-sitosterol/polyethylene glycol complex.
Alqarni, Ali, "Beta-sitosterol/polyethylene glycol complexes as drug delivery vehicles" (2015). ETD Collection for AUC Robert W. Woodruff Library. 3040.