Date of Award
University or Center
Clark Atlanta University(CAU)
School of Arts and Sciences
Dr. David B. Cooke, III
Cancer cell attachment to and invasion of an extracellular matrix has been associated with metastatic potential. Recently it has become apparent that the extracellular matrix may influence several phenotype properties of metastatic cancer cells. The mechanisms which regulate prostate cancer growth and metastasis may be particularly relevant to the development of clinical strategies for better understanding and ultimate treatment and control of the disease.
Cell-matrix interactions of prostate tumor cells were investigated by comparing the invasive ability through and attachment to reconstructed extracellular matrix components. A correlation was found between metastatic potential and adhesive ability. Non-metastatic AT-1 cells possessed a higher adhesive potential to extracellular matrix components than the highly metastatic cells (Mat-Lu, Mat-LyLu and AT-3) which had higher invasive potentials.
Donald, Carlton Dewitt, "Cytoskeletal Dynamics and cellular differentiation influence tumor progression and metastatic potential in Prostate Adenocarcinoma" (1997). ETD Collection for AUC Robert W. Woodruff Library. 3298.