Date of Award

8-1-1978

Degree Type

Thesis

Degree Name

M.S.

Department

Department of Biology

First Advisor

Dr. Joseph B. Myers

Abstract

This investigation was conducted to measure the glomerular filtration rate (GFR) and urine output of one-kidney Goldblatt (1-kG) and two-kidney Goldblatt (2-kG) renal ischemic Sprague-Dawley rats. Renal ischemia was produced by partial constriction of the left renal artery with a silver clip and removing the contralateral kidney (1-kG) or leaving the contralateral kidney intact (2-kG). Results showed that the 1-kG and 2-kG experimental rats GFRs and urine output were less than their respective controls. Variations in these results were produced as a result of internal factors of the ischemic kidneys, mainly a decrease in the number of glomeruli, the total surface area of glomerular membrane and the filtration pressure of glomerular capillaries.

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