Date of Award
Department of Biology
Dr. Joseph B. Myers
This investigation was conducted to measure the glomerular filtration rate (GFR) and urine output of one-kidney Goldblatt (1-kG) and two-kidney Goldblatt (2-kG) renal ischemic Sprague-Dawley rats. Renal ischemia was produced by partial constriction of the left renal artery with a silver clip and removing the contralateral kidney (1-kG) or leaving the contralateral kidney intact (2-kG). Results showed that the 1-kG and 2-kG experimental rats GFRs and urine output were less than their respective controls. Variations in these results were produced as a result of internal factors of the ischemic kidneys, mainly a decrease in the number of glomeruli, the total surface area of glomerular membrane and the filtration pressure of glomerular capillaries.
Middleton, Stewart, "A study of the glomerular filtration rate and urine output in renal ischemic sprague-dawley rats" (1978). ETD Collection for AUC Robert W. Woodruff Library. 3446.