Date of Award


Degree Type


Degree Name



Department of Biology


This investigation involved the determination of renal function in rats during a period of experimental hypertension. Rats were rendered hypertensive by partially ligating the left renal artery and removing the right kidney* A unilateral nephrectomy was performed on the experimental rats, and controls (both kidneys present) were used as comparative groups. Renal function tests consisted of plasma clearance of inulin and phenol red retention determinations. The per cent of body weight of the kidney, heart and adrenal glands were determined. The results of this work suggested that albino rat kidneys can function during a period of stress so long as a level of systemic exhaustion is not exceeded. The term systemic exhaustion mentioned here has reference to two factors (endocrine and vascular), which elicited a response along with the renin-angiotonin mechanism.