Hexaminecobalt (III) chloride and ruthenium red inhibited calcium uptake in nervous tissue, 1991

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Title: Hexaminecobalt (III) chloride and ruthenium red inhibited calcium uptake in nervous tissue, 1991
Author: Williamson, George D.
Decade: 1990-1999
Abstract: The effects of ruthenium red and hexaminecobalt (III) chloride on Ca2+ transport and mitochondrial respiration were studied. Low levels of ruthenium red and hexaminecobalt (III) chloride (3-6 nmoles/ng mitochondrial protein) completely inhibited the stimulation of respiration by Ca2+ but had no effect on State 3 respiration. Ruthenium red and hexaminecobalt also inhibited respiration-dependent and ATP-supported Ca2+ uptake as well as the metabolism-independent and high- and low-affinity binding of Ca2+; although, neither had an effect on the release of accumulated Ca2+. Concentrations higher than (7 nmoles/mg mitochondrial protein) prevent Ca2+ binding and transport; markedly inhibit/alter hexaminecobalt (III) chloride and ruthenium red (state 4) respirations, but however, did not prevent stimulation of respiration by ADP.
Document Type: text
Format: application/pdf
Date of Award: 1991-07-01
Degree Type: thesis
Degree Name: Master of Science (MS)
Granting Institution: Clark Atlanta University
Department: School of Arts and Sciences, Biology
Advisor: Moore, Cyril L.
Institution: Clark Atlanta University
Geographic Location: Georgia--Atlanta
Handle: http://hdl.handle.net/20.500.12322/cau.td:1991_williamson_george_d