Date of Award

7-1-1991

Degree Type

Thesis

University or Center

Clark Atlanta University(CAU)

School

School of Arts and Sciences

Degree Name

M.S.

Department

Biology

First Advisor

Dr. Cyril L. Moore

Abstract

The effects of ruthenium red and hexaminecobalt (III) chloride on Ca2+ transport and mitochondrial respiration were studied. Low levels of ruthenium red and hexaminecobalt (III) chloride (3-6 nmoles/ng mitochondrial protein) completely inhibited the stimulation of respiration by Ca2+ but had no effect on State 3 respiration. Ruthenium red and hexaminecobalt also inhibited respiration-dependent and ATP-supported Ca2+ uptake as well as the metabolism-independent and high- and low-affinity binding of Ca2+; although, neither had an effect on the release of accumulated Ca2+. Concentrations higher than (7 nmoles/mg mitochondrial protein) prevent Ca2+ binding and transport; markedly inhibit/alter hexaminecobalt (III) chloride and ruthenium red (state 4) respirations, but however, did not prevent stimulation of respiration by ADP.

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