Date of Award

5-1-2009

Degree Type

Dissertation

University or Center

Clark Atlanta University(CAU)

School

School of Arts and Sciences

Degree Name

Ph.D.

Department

Chemistry

First Advisor

Dr. Ishrat M. Khan

Second Advisor

Dr. James L. Reed

Third Advisor

Dr. Roosevelt Thedford

Abstract

A series of DNP (2,4-dinitrophenyl)functionalized polypyrrole polymers that are specific to antibodies and immune receptors on cell have been synthesized and characterized (See Figure). This is a terpolymer composed of three monomers; monomer 1 (M1, pyrrole), macromonomer 2 (M2, pyrrole with pendant ethylene glycol) and macromonomer 3 (M3, pyrrole with pendant DNP). These polymers are expected to be useful for controlling receptor binding and cell activation, and with eventual application in biosensors. Conductivity measurement indicate that the terpolymers are conductive, without adding external doping agents conductivity values of 5 x 1 06 S cm ‘(at 25 °C) were obtained. Binding studies with anti-DNP IgE studies are promising, fraction of binding sites occupied vs. concentration indicates specific and efficient binding at nanomolar concentration. Therefore, DNP functionalized polypyrrole are excellent materials for preparing nanowires in biosensors for detecting biomarkers. We have also determined that these polymers are biocompatible. Nanowires are currently being fabricated using the functionalized conductive polymers. In addition to synthesis and characterization, the thermal properties of the functional polymers will be discussed with regards to the fabrication of nanowires for biosensing applications.

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