Date of Award

12-1-1978

Degree Type

Thesis

University or Center

Atlanta University (AU)

Degree Name

M.S.

Department

Chemistry

First Advisor

Professor Malcolm B. Polk

Abstract

A synthesis is described for a number of 16,16-dimethyl analogs of the prostacyclin and related 6-keto prostaglandin types. Included are l6, l6-dimethyl-PGI2 sodium salt (XLIV), 6α-l6, l6-dimethyl-PGI1(XLV), 6β-l6, l6-dimethyl-PGI1 (XLVII), 6-keto-l6, l6-dimethyl-PGF1-α (XLIX), and 6-keto-l6, l6-dimethyl PGE1 (LV). Done, but not included, is the activity for these analogs in the blood platelet aggregation inhibition assay. This activity was consistently less than for the corresponding 16, 16-dihydro compounds.

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