Synthesis of a series of 16, 16-dimethyl-prostacyclin and 6-keto prostaglandin analogs, 1978

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Title: Synthesis of a series of 16, 16-dimethyl-prostacyclin and 6-keto prostaglandin analogs, 1978
Author: Yearell, Cheryl D.
Decade: 1970-1979
Abstract: A synthesis is described for a number of 16,16-dimethyl analogs of the prostacyclin and related 6-keto prostaglandin types. Included are l6, l6-dimethyl-PGI2 sodium salt (XLIV), 6?-l6, l6-dimethyl-PGI1(XLV), 6?-l6, l6-dimethyl-PGI1 (XLVII), 6-keto-l6, l6-dimethyl-PGF1-? (XLIX), and 6-keto-l6, l6-dimethyl PGE1 (LV). Done, but not included, is the activity for these analogs in the blood platelet aggregation inhibition assay. This activity was consistently less than for the corresponding 16, 16-dihydro compounds.
Document Type: text
Format: application/pdf
Date of Award: 1978-12-01
Degree Type: thesis
Degree Name: Master of Science (MS)
Granting Institution: Atlanta University
Department: Chemistry
Advisor: Polk, Malcolm B.
Institution: Clark Atlanta University
Geographic Location: Georgia--Atlanta
Handle: http://hdl.handle.net/20.500.12322/cau.td:1978_yearell_cheryl_d