Red blood cell ageing and the ability of their microparticle to protect human endothelial cells from oxidative stress

Delsarte, Llewellyn R.
Lawson, Charlotte
Bose, Nripendra R.

2013

2010-2019

Red blood cells (RBCs) have various roles that are important in making sure that the body functions properly. They are responsible for delivering oxygen and removing carbon dioxide and other waste gases to and from the body. Studies have shown that storing the blood for extended amounts of time leads to more oxygen entering the blood, causing oxidative stress and also formation of microparticles. Small in size (<1 micron), microparticles are membrane vesicles that are released by RBCs and other types of cells such as platelets, leukocytes, and endothelial cells. It has been shown that microparticles are increased in the plasma of patients with cardiovascular disease, however conflicting evidence has lead to the idea that the increased release of microparticles may be harmful to patient care. Other research findings suggest that microparticles derived from RBCs are actually protective against pro-inflammatory signals in endothelial cells. The aim of this project was to test the hypothesis that microparticles from younger red blood cells protect against oxidative stress signals in human endothelial cells, and as they age, if they enhance the oxidative stress response.

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conference proceedings

Enhancing Global Research and Education in STEM at Spelman College (G-STEM)

Chemistry|Biochemistry

Spelman College

Georgia--Atlanta

http://hdl.handle.net/20.500.12322/sc.gstem:2013_delsarte_llewllyn_r

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